Study: People worldwide living longer, but sicker

LONDON (AP) — Nearly everywhere around the world, people are living longer and fewer children are dying. But increasingly, people are grappling with the diseases and disabilities of modern life, according to the most expansive global look so far at life expectancy and the biggest health threats.

The last comprehensive study was in 1990 and the top health problem then was the death of children under 5 — more than 10 million each year. Since then, campaigns to vaccinate kids against diseases like polio and measles have reduced the number of children dying to about 7 million.

Malnutrition was once the main health threat for children. Now, everywhere except Africa, they are much more likely to overeat than to starve.

With more children surviving, chronic illnesses and disabilities that strike later in life are taking a bigger toll, the research said. High blood pressure has become the leading health risk worldwide, followed by smoking and alcohol.

"The biggest contributor to the global health burden isn't premature (deaths), but chronic diseases, injuries, mental health conditions and all the bone and joint diseases," said one of the study leaders, Christopher Murray, director of the Institute of Health Metrics and Evaluation at the University of Washington.

In developed countries, such conditions now account for more than half of the health problems, fueled by an aging population. While life expectancy is climbing nearly everywhere, so too are the number of years people will live with things like vision or hearing loss and mental health issues like depression.

The research appears in seven papers published online Thursday by the journal Lancet. More than 480 researchers in 50 countries gathered data up to 2010 from surveys, censuses and past studies. They used statistical modeling to fill in the gaps for countries with little information. The series was mainly paid for by the Bill & Melinda Gates Foundation.

As in 1990, Japan topped the life expectancy list in 2010, with 79 for men and 86 for women. In the U.S. that year, life expectancy for men was 76 and for women, 81.

The research found wide variations in what's killing people around the world. Some of the most striking findings highlighted by the researchers: — Homicide is the No. 3 killer of men in Latin America; it ranks 20th worldwide. In the U.S., it is the 21st cause of death in men, and in Western Europe, 57th.

— While suicide ranks globally as the 21st leading killer, it is as high as the ninth top cause of death in women across Asia's "suicide belt," from India to China. Suicide ranks 14th in North America and 15th in Western Europe.

— In people aged 15-49, diabetes is a bigger killer in Africa than in Western Europe (8.8 deaths versus 1 death per 100,000).

— Central and Southeast Asia have the highest rates of fatal stroke in young adults at about 15 cases per 100,000 deaths. In North America, the rate is about 3 per 100,000.

Globally, heart disease and stroke remain the top killers. Reflecting an older population, lung cancer moved to the 5th cause of death globally, while other cancers including those of the liver, stomach and colon are also in the top 20. AIDS jumped from the 35th cause of death in 1990 to the sixth leading cause two decades later.

While chronic diseases are killing more people nearly everywhere, the overall trend is the opposite in Africa, where illnesses like AIDS, malaria and tuberculosis are still major threats. And experts warn again shifting too much of the focus away from those ailments.

"It's the nature of infectious disease epidemics that if you turn away from them, they will crop right back up," said Jennifer Cohn, a medical coordinator at Doctors Without Borders.

Still, she acknowledged the need to address the surge of other health problems across Africa. Cohn said the agency was considering ways to treat things like heart disease and diabetes. "The way we treat HIV could be a good model for chronic care," she said.

Others said more concrete information is needed before making any big changes to public health policies.

"We have to take this data with some grains of salt," said Sandy Cairncross, an epidemiologist at the London School of Hygiene and Tropical Medicine.

He said the information in some of the Lancet research was too thin and didn't fully consider all the relevant health risk factors.

"We're getting a better picture, but it's still incomplete," he said.

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Online:

www.lancet.com

http://healthmetricsandevaluation.org

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North Korea rocket launch raises nuclear stakes

SEOUL/TOKYO (Reuters) - North Korea successfully launched a rocket on Wednesday, boosting the credentials of its new leader and stepping up the threat the isolated and impoverished state poses to opponents.

The rocket, which North Korea says put a weather satellite into orbit, has been labeled by the United States, South Korea and Japan as a test of technology that could one day deliver a nuclear warhead capable of hitting targets as far away as the continental United States.

"The satellite has entered the planned orbit," a North Korean television news reader clad in traditional Korean garb announced, after which the station played patriotic songs with the lyrics "Chosun (Korea) does what it says".

The rocket was launched just before 10 a.m. (0100 GMT), according to defense officials in South Korea and Japan, and was more successful than a rocket launched in April that flew for less than two minutes.

The North American Aerospace Defense Command (NORAD), a joint U.S.-Canadian military organization, said that the missile had "deployed an object that appeared to achieve orbit".

North Korea followed what it said was a similar successful launch in 2009 with a nuclear test that prompted the U.N. Security Council to stiffen sanctions that it originally imposed in 2006 after the North's first nuclear test.

North Korea is banned from developing nuclear and missile-related technology under U.N. resolutions, although Kim Jong-un, the youthful head of state who took power a year ago, is believed to have continued the state's "military first" programs put in place by his late father, Kim Jong-il.

North Korea hailed the launch as celebrating the prowess of all three members of the Kim family to rule since it was founded in 1948.

"At a time when great yearnings and reverence for Kim Jong-il pervade the whole country, its scientists and technicians brilliantly carried out his behests to launch a scientific and technological satellite in 2012, the year marking the 100th birth anniversary of President Kim Il Sung," its KCNA news agency said. Kim Il Sung, the current leader's grandfather, was North Korea's first leader.

The United States condemned the launch as "provocative" and a breach of U.N. rules, while Japan's U.N. envoy called for a Security Council meeting. However, diplomats say further tough sanctions are unlikely from the Security Council as China, the North's only major ally, will oppose them.

"The international community must work in a concerted fashion to send North Korea a clear message that its violations of United Nations Security Council resolutions have consequences," the White House said in a statement.

U.S. intelligence has linked North Korea with missile shipments to Iran. Newspapers in Japan and South Korea have reported that Iranian observers were in the North for the launch, something Iran has denied.

Japan's likely next prime minister, Shinzo Abe, who is leading in opinion polls ahead of an election on Sunday and who is known as a hawk on North Korea, called on the United Nations to adopt a resolution "strongly criticizing" Pyongyang.

A North Korean Foreign Ministry spokesman reiterated that the rocket was a "peaceful project".

"The attempt to see our satellite launch as a long-range missile launch for military purposes comes from hostile perception that tries to designate us a cause for security tension," KCNA cited the spokesman as saying.

"STUMBLING BLOCK"

China had expressed "deep concern" prior to the launch which was announced a day after a top politburo member, representing new Chinese leader Xi Jinping, met Kim Jong-un in Pyongyang.

On Wednesday, its tone was measured, regretting the launch but calling for restraint on any counter-measures, in line with a policy of effectively vetoing tougher sanctions.

"China believes the Security Council's response should be cautious and moderate, protect the overall peaceful and stable situation on the Korean peninsula, and avoid an escalation," Chinese Foreign Ministry spokesman Hong Lei told journalists.

Bruce Klingner, a Korea expert at the Heritage Foundation, said: "China has been the stumbling block to firmer U.N. action and we'll have to see if the new leadership is any different than its predecessors."

A senior adviser to South Korea's president said last week it was unlikely there would be action from the United Nations and Seoul would expect its allies to tighten sanctions unilaterally.

Kim Jong-un, believed to be 29 years old, took power when his father died on December 17 last year and experts believe the launch was intended to commemorate the first anniversary of his death. The April launch was timed for the centennial of the birth of Kim Il Sung.

Wednesday's success puts the North ahead of the South which has not managed to get a rocket off the ground.

"This is a considerable boost in establishing the rule of Kim Jong-un," said Cho Min, an expert at the Korea Institute of National Unification.

There have been few indications the secretive and impoverished state, where the United Nations estimates a third of people are malnourished, has made any advances in opening up economically over the past year.

North Korea remains reliant on minerals exports to China and remittances from tens of thousands of its workers overseas.

Many of its 22 million people need handouts from defectors, who have escaped to South Korea, for basic medicines.

Given the puny size of its economy - per capita income is less than $2,000 a year - one of the few ways the North can attract world attention is by emphasizing its military threat.

It wants the United States to resume aid and to recognize it diplomatically, although the April launch scuppered a planned food deal.

The North is believed to be some years away from developing a functioning nuclear warhead although it may have enough plutonium for about half a dozen nuclear bombs, according to nuclear experts.

It has also been enriching uranium, which would give it a second path to nuclear weapons as it sits on big natural uranium reserves.

"A successful launch puts North Korea closer to the capability to deploy a weaponized missile," said Denny Roy, a senior fellow at the East-West Center in Hawaii.

"But this would still require fitting a weapon to the missile and ensuring a reasonable degree of accuracy. The North Koreans probably do not yet have a nuclear weapon small enough for a missile to carry."

The North says its work is part of a civil nuclear program although it has also boasted of it being a "nuclear weapons power".

(This story has been refiled to clarify reference to NORAD in paragraph five)

(Additional reporting by Jumin Park and Yoo Choonsik in SEOUL; David Alexander, Matt Spetalnick and Paul Eckert in WASHINGTON; Linda Sieg in TOKYO, Sui-Lee Wee and michael Martina in BEIJING,; Rosmarie Francisco in MANILA; Writing by David Chance; Editing by Raju Gopalakrishnan and Robert Birsel)

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Asian markets mostly up after Fed move

HONG KONG: Asian stock markets mostly rose Thursday as the US Federal Reserve announced fresh monetary easing and said it would not lift interest rates until unemployment was under control.

However, the gains were capped after the central bank's chief Ben Bernanke said the looming fiscal cliff of huge tax hikes and deep spending cuts was already hitting the economy.

The yen continued its slide ahead of the weekend's general election in Japan that is expected to see a victory for the opposition, whose leader has vowed to press for more aggressive measures to kickstart growth.

Tokyo climbed 1.15 per cent, lifted by the weakening yen, Hong Kong gained 0.22 per cent, Sydney added 0.10 per cent and Seoul was 0.60 per cent higher, but Shanghai lost 0.36 per cent.

After a two-day meeting the policy committee of the US central bank said it would replace its "Operation Twist" bond swapping programme with $45 billion a month in straight bond buys, on an open-ended basis.

That comes on top of the $40 billion a month purchasing announced in September.

The Fed also provided a surprise by saying it would not lift rates as long as the inflation outlook was below 2.5 per cent and the jobless rate, now at 7.7 per cent, stays above 6.5 per cent.

"The Fed's decisions did not really surprise anyone, although its comments about expecting rates to remain very low as long as unemployment remains above 6.5 per cent were somewhat novel," said Hiroichi Nishi, general manager of equities at SMBC Nikko Securities.

"The bottom line is that it will continue its aggressive steps to foster economic growth," he told Dow Jones Newswires.

However, the Fed's announcement was followed by a warning by Bernanke that Washington needed to come to an agreement in their talks on avoiding the fiscal cliff, adding that the lack of action was already causing problems.

"Even though we have not even reached the point of the fiscal cliff potentially kicking in, it's already affecting business investment and hiring decisions by creating uncertainty or creating pessimism," he said at a news conference.

On Wall Street the Dow and S&P 500 ended flat, while the Nasdaq fell 0.28 per cent, with earlier gains from the Fed announcement cut back by Bernanke's comments.

On currency markets the yen remained under pressure as Sunday's poll approaches, with Prime Minister Yoshihiko Noda's Democratic Party of Japan likely to lose to the Liberal Democratic Party, which is headed by Shinzo Abe.

Abe, a former prime minister, has promised to push a more aggressive monetary easing policy to jumpstart the economy.

The dollar was changing hands at 83.42 yen in early Asian trade, from 83.24 yen in New York late Wednesday, while the euro was at 108.95 yen from 108.85 yen. That compares with 82.67 yen and 107.48 yen earlier on Wednesday in Asia.

The euro bought $1.3063 against $1.3075.

Oil was lower in Asia Thursday, with New York's main contract, light sweet crude for delivery in January, falling 19 cents to $86.58 a barrel and Brent North Sea crude for January delivery shedding 15 cents to $109.35.

Gold was at $1,699.60 at 0230 GMT compared with $1,713.22 late Wednesday.

- AFP/ck

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Chilkur temple stage for Pandit Shankar’s secret wedding

HYDERABAD: For the older priests of the Balaji temple in Chilkur, the news of Pandit Ravi Shankar's sudden demise brought back vivid memories of the day he landed in Hyderabad and paid them a quiet visit, taking them all by surprise.

Not many people know but the sitar maestro married Sukanya Devi, mother of Anoushka Shankar in 1989 at the very temple, when it was frequented by only a handful of devotees.

"They came in a car on that day with their own purohit and nobody had even a faint idea that the marriage of a celebrity was going to take place," said M V Soundara Rajan, hereditary trustee of the Chilkur Balaji temple . "The temple authorities were not informed beforehand. It was a very low-key and simple affair bereft of any celebrity wedding. The marriage ritual was finished within an hour and the guests left soon," recalls Rajan, whose 99-year-old uncle C M Srinivasa Raghava Chary performed the marriage. The maestro, according to temple authorities, was a big devotee of Balaji and had visited the temple several times. Popularly known as the "visa god" as students pray there before applying for visa counseling, the temple witnesses over 5000 people visiting it every day.

Back in the days, the temple was very popular among members of Gujarati and Marwari community from the city who were ardent devotees of the lord.

A Gujarati businessman from the city, who was the patron of the temple, was instrumental in getting Ravi Shankar married here, priests say. "Ravi Shankar was a close friend of a Gujarati devotee who used to visit our temple. Probably this was the reason why he chose this temple. He had accompanied Ravi Shankar and his would-be wife to the temple that day," Rajan recalled.

Soundara Rajan also remembered the Gujarati devotee, whose name he does not remember , speaking of organizing a benefit programme with Ravi Shankar and promising to donate its proceeds to the development of the temple. "But our family had rejected that idea since we did not want any monetary help raised through such programmes since we consider this as a service," he said.

Recalling the marriage, priests said the marriage at this temple would have been confidential and not known to many had it not been for a lucky reporter who stumbled on the information . "Only after the news was splashed many knew that he had visited the city" a priest said.

According to them, Ravi Shankar also chose the temple as he was also a devotee of Chilkur Balaji. "He seemed to have visited the temple before and after the marriage."

C S Rangarajan, chief priest of the temple and son of Soundara Rajan recalled his conversation on this topic with his grandfather , who was the in-charge of the temple then. "This temple might have been chosen because it was quiet and hardly visited by any devotees. He had visited again in 2009 which showed he had faith in Chilkur Balaji," Rangarajan added.

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Congress examines science behind HGH test for NFL

WASHINGTON (AP) — A congressional committee has opened a hearing to examine the science behind a human growth hormone test the NFL wants to start using on its players.

Nearly two full seasons have passed since the league and the players' union signed a labor deal that set the stage for HGH testing.

The NFL Players Association won't concede the validity of a test that's used by Olympic sports and Major League Baseball, and the sides haven't been able to agree on a scientist to help resolve that impasse.

Among the witnesses before the House Oversight and Government Reform Committee on Wednesday is Pro Football Hall of Fame member Dick Butkus. In his prepared statement, Butkus writes: "Now, let's get on with it. The HGH testing process is proven to be reliable."

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Shooter Kills Self After Oregon Mall Rampage

A masked gunman opened fire today at Clackamas Town Center, a mall in suburban Portland, Ore., killing two people, injuring one, and then killing himself.

"I can confirm the shooter is dead of an apparent self inflicted gunshot wound," Lt. James Rhodes of the Clackamas County, Ore., Sheriff's Department said today. "By all accounts there were no rounds fired by law enforcement today in the mall."

Police have not released the names of the deceased. Rhodes said authorities are in the process of notifying victims' families. The injured victim has been transported to a local hospital.

Rhodes described the shooter as an adult male.

Witnesses from the shooting rampage said that a young man in a white hockey mask and bulletproof vest tore through the Macy's, food court, and mall hallways firing rounds at shoppers beginning around 3:30 p.m. PT today.

Hundreds of people were evacuated from the busy mall full of holiday shoppers after the shooting began.

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The gunman entered the mall through a Macy's store, ran through the upper level of Macy's and opened fire near the mall food court, firing multiple shots, one right after another, with what is believed to be a black, semiautomatic rifle, according to witness reports.

Katie Tate said she was in the parking lot of the mall when she saw the shooter run by, wearing a mask and carrying a machine gun, headed for the Macy's.

"He looked like a teenager wearing a gun, like a bullet-proof vest and he had a machine, like an assault rifle and a white mask and he looked at me," she said.

Witnesses described the shooter as being on a mission and determined, looking straight ahead. He then seemed to walk through the mall toward the other end of the building, shooting along the way, according to witness reports.

Those interviewed said that Macy's shoppers and store employees huddled in a dressing room to avoid being found.

"I was helping a customer in the middle of the store, her and her granddaughter and while we were looking at sweatshirts we heard five to seven shots from a machine gun fire just outside my store," Jacob Rogers, a store clerk, told ABC affiliate KATU-TV in Portland.

"We moved everyone into the back room where there's no access to outside but where there's a camera so we can monitor what's going on out front," Rogers said.

Evan Walters, an employee at a store in the mall, told ABC News Radio that he was locked in a store for his safety and he saw two people shot and heard multiple gunshots.

"It was over 20, and it was kind of surreal because we hear pops and loud noises," he said. "We're next to the food court here and we hear pops and loud noises all the time, but we don't -- nothing like that. It was very definite gunshots."

Police are tracing the weapon used in the shooting.

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North Korea's new leader burnishes credentials with rocket

SEOUL/TOKYO (Reuters) - North Korea successfully launched a rocket on Wednesday, boosting the credentials of its new leader and stepping up the threat the isolated and impoverished state poses to its opponents.

The rocket, which North Korea says was designed to put a weather satellite into orbit, has been labeled by the United States, South Korea and Japan as a test of technology that could one day deliver a nuclear warhead capable of hitting targets as far as the continental the United States.

"The satellite has entered the planned orbit," North Korea's state news agency KCNA said.

North Korea followed what it said was a similar successful launch in 2009 with a nuclear test that prompted the United Nations Security Council to stiffen sanctions against Pyongyang that it originally imposed in 2006 after the North's first nuclear test.

The state is banned from developing nuclear and missile-related technology under U.N. resolutions, although Kim Jong-un, the youthful head of state who took power a year ago, is believed to have continued the state's "military first" programs put into place by his deceased father Kim Jong-il.

After Wednesday's launch, which saw the second stage of the rocket splash down in seas off the Philippines as planned, Japan's U.N. envoy called for a Security Council meeting. However, diplomats say further tough sanctions are unlikely to be agreed at the body as China, the North's only major ally, will oppose them.

The rocket was launched just before 10 a.m. Korea time (9 p.m. ET on Tuesday), according to defense officials in South Korea and Japan, and easily surpassed a failed April launch that flew for less than two minutes.

There was no independent confirmation it had put a satellite into orbit.

Japan's likely next prime minister, Shinzo Abe, who is leading in opinion polls ahead of an election on December 16 and who made his name as a North Korea hawk, called on the United Nations to adopt a resolution "strongly criticizing" Pyongyang.

There was no immediate official reaction from Washington, South Korea's major military backer, or from China.

China had expressed "deep concern" over the launch which was announced a day after a visit by a top politburo member to Pyongyang when he met Kim Jong-un.

On Wednesday, China's state news agency Xinhua said North Korea had the "right to conduct peaceful exploration of outer space."

But it added: "Pyongyang should also abide by relevant U.N. Security Council resolutions, including Resolution 1874, which demands (North Korea) not to conduct 'any launch using ballistic missile technology' and urges it to 'suspend all activities related to its ballistic missile program.'"

U.S. Representative Ileana Ros-Lehtinen, a Florida Republican who heads the House of Representatives Foreign Affairs Committee, quickly condemned the launch and called for tougher sanctions.

"It is clear that Pyongyang is moving ever closer towards its ultimate goal of producing a nuclear ballistic missile in order to threaten not only our allies in the Asia-Pacific region but the U.S. as well," she said.

A senior adviser to South Korea's president said last week it was unlikely that there would be a meaningful set of sanctions agreed at the United Nations but that Seoul would expect its allies to tighten sanctions unilaterally.

A YEAR ON FOR THE THIRD KIM

Kim Jong-un, believed to be 29 years old, took office after his father died on December 17 last year and experts believe that Wednesday's launch was intended to commemorate the first anniversary of the death.

The April launch was timed for the centennial of the birth of Kim Il Sung, the founder of North Korea and the grandfather of its current ruler.

"This is a considerable boost in establishing the rule of Kim Jong-un," said Cho Min, an expert at the Korea Institute of National Unification.

There have been few indications the secretive and impoverished state, where the United Nations estimates a third of the population is malnourished, has made any advances in opening up economically over the past year.

North Korea remains reliant on minerals exports to China and remittances from tens of thousands of its people working on labor projects overseas.

The 22 million population often needs handouts from defectors who have escaped to South Korea in order to afford basic medicines.

Given the puny size of its economy - per capita income is less than $2,000 a year - one of the few ways that North Korea can attract world attention is by emphasizing its military threat.

Pyongyang wants the United States to resume aid and to recognize it diplomatically, although the April launch skippered a planned food deal.

It is believed to be some years away from developing a functioning nuclear warhead and to have enough plutonium for around half a dozen nuclear bombs, according to nuclear experts.

The North has also been enriching uranium which would give it a second path to nuclear weapons as it sits on vast natural uranium reserves.

It says that its development is part of a civil nuclear program, but has also boasted of it being a "nuclear weapons power".

(Additional reporting by Jumin Park and Yoo Choonsik in SEOUL; Writing by David Chance; Editing by Raju Gopalakrishnan)

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Equipment failure could have caused incident that left serviceman critically injured

SINGAPORE: Preliminary findings indicate equipment malfunction could have led to the incident that left a navy serviceman critically injured.

The Ministry of Defence (MINDEF) in an update late Tuesday night said Weapon Systems Supervisor Jason Chee Weng Fai remains in critical condition.

He's warded at the Changi General Hospital.

Channel NewsAsia understands that Mr Chee is expected to be in the Intensive Care Unit for a few days.

The Republic of Singapore Navy (RSN) declared a 48-hour safety time-out from 10 Dec for its Frigates, Missile Corvettes and Landing Ship Tanks.

MINDEF said the safety time-out will allow the RSN to review its operating and safety procedures.

The Military Expert was injured on Monday when he got caught between a motorised winch and a rope, on the Landing Ship Tank, RSS Endeavour.

He was checking on a berthing rope that was being tightened when the incident happened.

- CNA/ck

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Seemandhra leaders vow to scuttle Telangana-meet

HYDERABAD: Invoking Telugu pride, Seemandhra Congress leaders on Tuesday vowed to ensure that the all-party meeting on Telangana does not happen on December 28 in view of the three-day World Telugu Conference slated to be held in Tirupati from December 27-29.

"If the Telangana Congress leaders think they can have their way in extracting a forward movement on the separate state demand in return for their vote on FDI in retail in the Lok Sabha, the Seemandhra leaders too can lobby to ensure that the all-party meeting does not happen on December 28," said a senior Congress leader.

"The World Telugu Conference must be the top priority for any Telugu-speaking person irrespective of his region in the state. When such an important event is happening, talking about the division of the state would be an insult to Telugu heritage, which is greater than politics. We have asked the Centre to convene the all-party meeting on December 20. If that is not possible, the Centre should consider holding the meeting in January 2013," Guntur Congress MP Rayapati Samabasiva Rao told TOI.

It's inevitable to postpone the all-party meet, claimed Vijayawada Congress MP Lagadapati Rajagopal. "We hope the Centre would not play with the sentiments of the people of the state. Any policy must be made on the basis of a democratic process and official procedures. We have brought this to the notice of the Centre, and it is up to them to take a call," Lagadapati said. Meanwhile, Samaikhyandhra Parirakshana Samithi (SPS) has lined up a series of demonstrations starting December 13 in a bid to put pressure on the Centre to postpone the all-party meeting. "We would take out separate padayatras across Seemandhra demanding the rescheduling of the all-party meeting. If the Centre does not oblige, then we will intensify the agitation," said Naraharisetty Srihari, president of SPS.

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DA investigating Texas' troubled $3B cancer agency

AUSTIN, Texas (AP) — Turmoil surrounding an unprecedented $3 billion cancer-fighting effort in Texas worsened Tuesday when its executive director offered his resignation and the state's chief public corruption prosecutor announced an investigation into the beleaguered agency.

No specific criminal allegations are driving the latest probe into the Cancer Prevention and Research Institute of Texas, said Gregg Cox, director of the Travis County district attorney's public integrity unit. But his influential office opened a case only weeks after the embattled agency disclosed that an $11 million grant to a private company bypassed review.

That award is the latest trouble in a tumultuous year for CPRIT, which controls the nation's second-largest pot of cancer research dollars. Amid the mounting problems, the agency announced Tuesday that Executive Director Bill Gimson had submitted his letter of resignation.

"Unfortunately, I have also been placed in a situation where I feel I can no longer be effective," Gimson wrote in a letter dated Monday.

Gimson said the troubles have resulted in "wasted efforts expended in low value activities" at the agency, instead of a focused fight against cancer. Gimson offered to stay on until January, and the agency's board must still approve his request to step down.

His departure would complete a remarkable house-cleaning at CPRIT in a span of just eight months. It began in May, when Dr. Alfred Gilman resigned as chief science officer in protest over a different grant that the Nobel laureate wanted approved by a panel of scientists. He warned it would be "the bomb that destroys CPRIT."

Gilman was followed by Chief Commercialization Officer Jerry Cobbs, whose resignation in November came after an internal audit showed Cobbs included an $11 million proposal in a funding slate without a required outside review of the project's merits. The lucrative grant was given to Dallas-based Peloton Therapeutics, a biomedical startup.

Gimson chalked up Peloton's award to an honest mistake and has said that, to his knowledge, no one associated with CPRIT stood to benefit financially from the company receiving the taxpayer funds. That hasn't satisfied some members of the agency's governing board, who called last week for more assurances that no one personally profited.

Cox said he has been following the agency's problems and his office received a number of concerned phone calls. His department in Austin is charged with prosecuting crimes related to government officials; his most famous cases include winning a conviction against former U.S. House Majority Leader Tom DeLay in 2010 on money laundering charges.

"We have to gather the facts and figure what, if any, crime occurred so that (the investigation) can be focused more," Cox said.

Gimson's resignation letter was dated the same day the Texas attorney general's office also announced its investigation of the agency. Cox said his department would work cooperatively with state investigators, but he made clear the probes would be separate.

Peloton's award marks the second time this year that a lucrative taxpayer-funded grant authorized by CPRIT instigated backlash and raised questions about oversight. The first involved the $20 million grant to M.D. Anderson Cancer Center in Houston that Gilman described as a thin proposal that should have first been scrutinized by an outside panel of scientific peer-reviewers, even though none was required under the agency's rules.

Dozens of the nation's top scientists agreed. They resigned en masse from the agency's peer-review panels along with Gilman. Some accused the agency of "hucksterism" and charting a politically-driven path that was putting commercial product-development above science.

The latest shake-up at CPRIT caught Gilman's successor off-guard. Dr. Margaret Kripke, who was introduced to reporters Tuesday, acknowledged that she wasn't even sure who she would be answering to now that Gimson was stepping down. She said that although she wasn't with the agency when her predecessor announced his resignation, she was aware of the concerns and allegations.

"I don't think people would resign frivolously, so there must be some substance to those concerns," Kripke said.

Kripke also acknowledged the challenge of restocking the peer-review panels after the agency's credibility was so publicly smeared by some of the country's top scientists. She said she took the job because she felt the agency's mission and potential was too important to lose.

Only the National Institutes of Health doles out more cancer research dollars than CPRIT, which has awarded more than $700 million so far.

Gov. Rick Perry told reporters in Houston on Tuesday that he wasn't previously aware of the resignation but said Gimson's decision to step down was his own.

Joining the mounting criticism of CPRIT is the woman credited with brainstorming the idea for the agency in the first place. Cathy Bonner, who served under former Texas Gov. Ann Richards, teamed with cancer survivor Lance Armstrong in selling Texas voters in 2007 on a constitutional amendment to create an unprecedented state-run effort to finance a war on disease.

Now Bonner says politics have sullied an agency that she said was built to fund research, not subsidize private companies.

"There appears to be a cover-up going on," Bonner said.

Peloton has declined comment about its award and has referred questions to CPRIT. The agency has said the company wasn't aware that its application was never scrutinized by an outside panel, as required under agency rules.

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Follow Paul J. Weber on Twitter: www.twitter.com/pauljweber

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